NUB1 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comNUB1 Polyclonal Antibody for Human(Homo sapiens)

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Index > Protein center > NUB1(Gene name) > Human

NUB1 (Gene name),

NEDD8 ultimate buster 1 (Protein name ), NUB1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

NUB1(NYREN18);

Protein name:

NEDD8 ultimate buster 1;

Alternative:

Renal carcinoma antigen NY-REN-18;Negative regulator of ubiquitin-like proteins 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Directly interacts with NEDD8 and PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome. Isoform 1 binds to NEDD8 more efficiently than isoform 2. Interacts with AIPL1. The interaction with UBD via UBA domains facilitates the linking of UBD-conjugated target protein to the proteasome complex and accelerates UBD degradation and that of its conjugates.

Function:

Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.

Subcellular Location:

Nucleus Predominantly nuclear.

Protein Attributes:

Sequence length:

615

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

615:

YLSYVENRKS | ATKKN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00627

MIM:

607981

KEGG:

hsa:51667

STRING:

9606.ENSP00000398644

SMR:

Q9Y5A7

String:

Q9Y5A7

UniGene:

Hs.647082

Uniprot:

Q9Y5A7

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ELISA Kit for Human NEDD8 ultimate buster 1

Cat.:

E15301b

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MSDS:

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Packing:

96T

ELISA Kit for Human NEDD8 ultimate buster 1

Cat.:

E15301m

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96T

ELISA Kit for Human NEDD8 ultimate buster 1

Cat.:

E15301h

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Packing:

96T

CLIA Kit for Human NEDD8 ultimate buster 1

Cat.:

U15301b

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MSDS:

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Packing:

96T

CLIA Kit for Human NEDD8 ultimate buster 1

Cat.:

U15301h

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MSDS:

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Packing:

96T

CLIA Kit for Human NEDD8 ultimate buster 1

Cat.:

U15301m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human NEDD8 ultimate buster 1

Cat.:

P15301Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human NEDD8 ultimate buster 1

Cat.:

P15301Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human NEDD8 ultimate buster 1

Protein for Human NEDD8 ultimate buster 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Antigens recognized by autologous antibody in patients with renal-cell carcinoma."
Scanlan M.J. , Gordan J.D. , Williamson B. , Stockert E. , Bander N.H. , Jongeneel C.V. , Gure A.O. , Jaeger D. , Jaeger E. , Knuth A. , Chen Y.-T. , Old L.J.
Int. J. Cancer83:456-464(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);IDENTIFICATION AS A RENAL CANCER ANTIGEN
tissue: Renal cell carcinoma.
2.

"NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression."
Kito K. , Yeh E.T.H. , Kamitani T.
J. Biol. Chem.276:20603-20609(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INTERACTION WITH NEDD8;SUBCELLULAR LOCATION;INDUCTION BY INTERFERONS
tissue: Heart.
3.

"Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L."
Tanaka T. , Kawashima H. , Yeh E.T.H. , Kamitani T.
J. Biol. Chem.278:32905-32913(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);CHARACTERIZATION;MUTAGENESIS OF ALA-448; LEU-453; LEU-464; LEU-468; LEU-587 AND LEU-591
tissue: Testis.
4.

"The DNA sequence of human chromosome 7."
Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Testis.
6.

Rump A. , Rosenthal A. , Drescher B. , Weber J. , Schattevoy R. , Korenberg J.
Submitted (2001-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-365
7.

"Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1."
Kamitani T. , Kito K. , Fukuda-Kamitani T. , Yeh E.T.H.
J. Biol. Chem.276:46655-46660(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PSMD4
8.

"The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1."
Akey D.T. , Zhu X. , Dyer M. , Li A. , Sorensen A. , Blackshaw S. , Fukuda-Kamitani T. , Daiger S.P. , Craft C.M. , Kamitani T. , Sohocki M.M.
Hum. Mol. Genet.11:2723-2733(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AIPL1
tissue: Retina.
9.

"NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation."
Hipp M.S. , Raasi S. , Groettrup M. , Schmidtke G.
J. Biol. Chem.279:16503-16510(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBD
10.

"The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10."
Schmidtke G. , Kalveram B. , Weber E. , Bochtler P. , Lukasiak S. , Hipp M.S. , Groettrup M.
J. Biol. Chem.281:20045-20054(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH UBD AND PROTEASOME;INDUCTION BY TNF AND IFNG
11.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"Solution structure of N-terminal ubiquitin-like domain of human NEDD8 ultimate buster-1."
RIKEN structural genomics initiative (RSGI)
Submitted (2006-01) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 75-161

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